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International Journal of Clinical & Medical Images

2376-0249

Clinical-Medical Image - International Journal of Clinical & Medical Images (2022) Volume 9, Issue 3

A Rare Case of Upper Gastrointestinal Bleeding: Osler-Weber-Rendu Syndrome.

A Rare Case of Upper Gastrointestinal Bleeding: Osler-Weber-Rendu Syndrome.

Author(s): Mouna Tamzaourte, Benayad Aourarh*, Sanae Berrag and Tarik Adioui

DOI: 10.4172/2376-0249.1000817

Received: 21 March 2022, Manuscript No. ijcmi-22-61370; Editor assigned: 23 March 2022, 2022, PreQC No. P-61370; Reviewed: 25 March 2022, QC No. Q-61370; Revised: 27 March 2022, Manuscript No. R-61370; Published: 30 March 2022, DOI: 10.4172/2376-0249.1000817

Clinical-Medical Image


A 65-year-old man, with no significant pathological history, was admitted for upper gastrointestinal bleeding, epistaxis and acute anemia.
Clinical examination showed melena on rectal examination. The complete blood count showed an iron deficiency anaemia at 6 g/dl which
required a transfusion followed by an iron infusion. Urgent upper gastrointestinal endoscopy revealed multiple and diffuse Telangiectasias
lesions located in the larynx, esophagus, entire stomach, and duodenum (Figures 1-3) suggestive of Osler-Weber-Rendu disease. Argon plasma
coagulation was performed on lesions with active bleeding during the same endoscopy. The patient was also treated with a proton pomp
inhibitor with a good clinical and biological evolution.
Osler-Weber-Rendu disease, also known as hereditary hemorrhagic telangiectasia, is a rare, autosomal dominant condition causing abnormal
blood vessel formation (arterio-venous malformations) [1]. The most common manifestation is nose bleeds (epistaxis). The telangiectasias can
also be located on the lips, tongue, buccal mucosa, face, chest, and fingers, however; large arterio-venous malformations can also occur in the
lungs, liver, pancreas, or brain [2]. When telangiectasias are found in the stomach and small bowel, they are responsible for chronic bleeding and
anemia. Arteriovenous malformations can develop in the hepatic parenchyma and be responsible for a portal hypertension syndrome with risk in the gastrointestinal tract.

Keywords: Osler-Weber-Rendu syndrome; Telangiectasia; Gastrointestinal bleeding


References


[1] Jargielo A, Rycyk A, Kasztelan-Szczerbinska B, & Cichoz-Lach H (2022). A Rare case of upper gastrointestinal bleeding: Osler-Weber-Rendu
Syndrome
. Medicina, 58:333-335.

Google Scholar Crossref

[2] Tortora A, Riccioni ME, Gaetani E, Ojetti V, and Holleran G, et al. (2019). Rendu-Osler-Weber disease: A gastroenterologist’s perspective.
Orphanet J Rare Dis 14: 1-4

Google Scholar Crossref PubMed

 

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Citations : 226

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