Clinical Image - International Journal of Clinical & Medical Images (2021) Volume 8, Issue 11
Author(s): Belkouchi Lina*, Aourarh Benayad and Saouab Rachida
A 33 years old woman, with no medical history record, was admitted in the ER for fever and consciousness disorder evolving for a few days [1-3]. The patient had received her second dose of Sars-CoV-2 vaccine 15 days before. Clinical exam revealed a GCS (Glasgow Coma Scale) of 13/15, a slight fever (38.5°C), and tetraparesia. Blood tests only showed a high CRP (C-reactive protein) level at 160 mg/L, with no sign of infection. Sars-CoV-2 PCR (Polymerase chain reaction) was negative. Cytotoxic lesions of the corpus callosum are caused by cytotoxic edema due to cytokines storm after infection, trauma, and sub-arachnoid hemorrhage, drug therapy such as seizure drugs, vaccination, metabolic disorders and malignancy.
Clinical symptoms aren’t specific
Brain MRI is specific, showing an oval shaped well-defined lesion of the splenium of the corpus callosum (Yellow arrow), with restriction in diffusion (B), non-enhanced with contrast (C), which is characteristic (Figure 1).
• Ischemic stroke of the anterior cerebral artery, however, this diagnosis is rare because of redundant blood supply.
• Acute disseminated encephalomyelitis that is more aggressive with asymmetric lesions. Treatment
• Treatment remains on steroids and immunoglobulin administration.
Keywords: Corpus; Callosum; Lesion; MRI
Declaration of Interests
The authors declare that they have no competing interests.
 Gaur P, Dixon L, Jones B, Lyall H, Jan W (2020) COVID-19-associated cytotoxic lesions of the corpus callosum. Am J Neuroradiol 41: 1905-1907.  Rasmussen C, Niculescu I, Patel S, Krishnan A (2020) COVID-19 and involvement of the corpus callosum: Potential effect of the cytokine storm. Am J Neuroradiol 41: 1625-1628.