international journal of clinical & medical images, clinical journals, medical journals, omics international, international journals, open access publication, scientific journals, free online medical journals, peer reviewed online journals, research, free online scientific articles
PHONE
+44-7482-878921

International Journal of Clinical & Medical Images

2376-0249

Medical Image - International Journal of Clinical & Medical Images (2014) Volume 1, Issue 5

Effects Of Nitrous Acid Exposure To Guinea Pigs

Effects Of Nitrous Acid Exposure To Guinea Pigs

Author(s): Ohyama Masayuki

Nitrous acid (HONO) exists as a gas in the atmosphere at ppb order and is not regulated. Few epidemiological studies have been performed to assess the association of HONO exposure with respiratory symptoms and lung function. Jarvis et al. (2005) observed that indoor HONO levels are associated with a decrease in lung function and possibly with additional respiratory symptoms [1]. A few inhalation studies have examined the relationship between the HONO exposure and respiratory symptoms and lung functions in mildly asthmatic adult subjects after a 3-h exposure to 0.65 ppm HONO [2] or in healthy adult nonsmokers after a 3.5-h exposure to 0.395 ppm HONO [3]. Our animal experiments using guinea pigs have demonstrated a yellowish orange pigmentation of the hairs of the guinea pigs (Figure 1), pulmonary emphysema-like alterations occur in the centriacinar regions of the alveolar ducts, and distortion of the centriacinar regions of alveolar ducts with extension of the bronchial epithelial cells and smooth muscle cells (Figure 2), in 3.6 ppm HONO exposure (24 h/day) for four weeks. In the future, numerous epidemiological studies and numerous animal exposure experiments of HONO should be carried out, and we anticipate that HONO will be regulated.

*Corresponding author: Ohyama Masayuki, Department of Environmental Health, Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025, Japan, Tel:+81-6-6972-1321; Fax: +81-6-6972-2393; E-Mail: ohyama@iph.pref.osaka.jp

flyer Image Awards Nomination
Indexing and Archiving
A generic square placeholder image with rounded corners in a figure.
All published articles are assigned to Digital Object Identifier (DOI)- CrossRef.
A generic square placeholder image with rounded corners in a figure.
All published articles of this journal are included in the indexing and abstracting coverage of:
Google Scholar citation report
Citations : 226

International Journal of Clinical & Medical Images received 226 citations as per Google Scholar report